Daily LC-MS Review Workflow

From LC-MS/MS Export to Run Decision

Upload the exported run data once. LC/MS-IQ performs the calibration, QC, peak, unknown, and instrument-health review automatically.

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Upload Exported Run Data

User action

Performed by: User

Start with the files your lab already exports. LC/MS-IQ reads the run data and prepares a structured review instead of forcing manual spreadsheet cleanup.

CSV/XML support Instrument run metadata Sample type recognition

Validate Peaks First

Automated by LC/MS-IQ

Performed by: LC/MS-IQ

Before calibration or QC decisions are trusted, LC/MS-IQ checks peak-level problems that can distort run interpretation.

Signal-to-noise checks Retention time windows Peak width review Missing or invalid peaks

Review Calibration

Automated by LC/MS-IQ

Performed by: LC/MS-IQ

Calibration is evaluated before QC and unknowns. If calibration fails for an analyte, downstream interpretation is blocked for that analyte.

Curve performance Calibrator bias Low signal flags Reason tracking

Evaluate QC Acceptance

Automated by LC/MS-IQ

Performed by: LC/MS-IQ

QC review determines whether an analyte is acceptable for unknown review. Failed QC stops unknown interpretation while preserving the failure reason.

QC bias QC signal quality Westgard-ready review Future trend eligibility

Determine Unknown Readiness

Automated by LC/MS-IQ

Performed by: LC/MS-IQ

Unknown samples are only evaluated after calibration and QC are acceptable for that analyte. This keeps reporting decisions aligned with the laboratory review sequence.

Ready for review Not evaluated when blocked Below-range visibility

Trend Method Health

Automated by LC/MS-IQ

Performed by: LC/MS-IQ

Accepted runs can feed historical health monitoring, helping laboratories see drift before it becomes a daily failure.

Retention time trends Signal-to-noise trends QC performance Analyte-level history

Decision Logic

Lab decision

Clear Statuses for Each Analyte

Performed by: Laboratory reviewer

LC/MS-IQ separates calibration, QC, and unknown readiness so the reason for a failed analyte is visible without mixing every issue into one generic status.

Calibration Failed QC and unknowns are not evaluated for that analyte.

QC Failed Unknowns are not evaluated until QC is acceptable.

Passed Calibration and QC are acceptable; unknowns are ready for review.

Build a Faster, Cleaner Daily Review

Create an account or request a demo to see how LC/MS-IQ can fit into your existing LC-MS review process.

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